GUT DYSBIOSIS WAS INEVITABLE, BUT TOLERANCE WAS NOT: TEMPORAL RESPONSES OF THE MURINE MICROBIOTA THAT MAINTAIN ITS CAPACITY FOR BUTYRATE PRODUCTION CORRELATE WITH SUSTAINED ANTINOCICEPTION TO CHRONIC MORPHINE

The therapeutic benefits of opioids are compromised by the development of analgesic tolerance, which necessitates higher dosing for pain management thereby increasing the liability for drug omnipure q5633 dependence and addiction.Rodent models indicate opposing roles of the gut microbiota in tolerance: morphine-induced gut dysbiosis exacerbates tol

Introduction In 1994, a group of scientists began discussing a number of important scientific questions that could be addressed by drilling a series of short cores on the Antarctic continental shelf.The group adopted the name SHALDRIL, for horseshoe chocolate mold SHALlow DRILling, and soon learned that the technology for high-quality sampling of t

In this paper, we proposed a contrast-enhanced homemade spectral domain optical coherence tomography (SD-OCT) method for monitoring of brain microcirculation.We used the polyethylene glycol (PEG)-ylated gold nanorods (GNRs) as a contrast-enhanced agent, obtained clearly 2D and 3D OCT images of blood vessels and dynamic changes of probes deauville m

Background & Aims: HBV-related acute-on-chronic liver failure (HBV-ACLF) is a severe acute liver injury secondary to HBV-related chronic liver disease (with or without cirrhosis) and is characterized by a high short-term mortality rate.Presently, there is a paucity of experimental models that specifically focus on HBV-ACLF based on chronic hepa

The coronavirus 2019 (COVID-19) pandemic has disproportionately impacted lesbian, gay, bisexual, transgender, queer (LGBTQ+) people.Despite developing safe and effective COVID-19 vaccines, LGBTQ+ communities still faces challenges due to inequitable access and vaccine hesitancy.Vaccine hesitancy is a delay in the acceptance or refusal of vaccines d